Dr. Campbell's China Study

T. Colin Campbell, Ph.D. is the author of The China Study, a multi-faceted and highly respected research project and book that demonstrates with solid science a number of the research principles Dr. Fuhrman discusses.

The China Study has its roots in Dr. Campbell's efforts as a young researcher to try to find ways to get people in developing countries to eat more animal protein like milk, eggs, and meat. Decades later, after one of the largest health research projects ever, he concludes that more animal protein does not inspire good health.

The research behind the China Study is far-reaching. In fact, it has been called the most comprehensive study of health and nutrition ever conducted, and it was the culmination of a 20-year partnership of Cornell University (where Dr. Campbell is a professor), Oxford University, and the Chinese Academy of Preventive Medicine.

As Dr. Campbell explains in the introduction of The China Study, he didn't set out to disprove many of the assumptions of American nutrition. It just worked out that way:

I was the last graduate student of Professor Clive McCay, a Cornell professor famed for extending the lives of rats by feeding them much less food than they would otherwise eat. My Ph.D. research at Cornell was devoted to finding better ways to make cows and sheep grow faster. I was attempting to improve on our ability to produce animal protein, the cornerstone of what I was told was "good nutrition."

I was on a trail to promote better health by advocating the consumption of more meat, milk and eggs. It was an obvious sequel to my own life on the farm and I was happy to believe that the American diet was the best in the world. Through these formative years, I encountered a recurring theme: we were supposedly eating the right foods, especially plenty of high-quality animal protein.

Much of my early career was spent working with two of the most toxic chemicals ever discovered, dioxin and aflatoxin. I initially worked at MIT, where I was assigned a chicken feed puzzle. Millions of chicks a year were dying from an unknown toxic chemical in their feed, and I had the responsibility of isolating and determining the structure of this chemical. After two and one-half years, I helped discover dioxin, arguably the most toxic chemical ever found. This chemical has since received widespread attention, especially because it was part of the herbicide 2,4,5-T, or Agent Orange, then being used to defoliate forests in the Vietnam War.

After leaving MIT and taking a faculty position at Virginia Tech, I began coordinating technical assistance for a nationwide project in the Philippines working with malnourished children. Part of the project became an investigation of the unusually high prevalence of liver cancer, usually an adult disease, in Filipino children. It was thought that high consumption of aflatoxin, a mold toxin found in peanuts and corn, caused this problem. Aflatoxin has been called one of the most potent carcinogens ever discovered.

For ten years our primary goal in the Philippines was to improve childhood malnutrition among the poor, a project funded by the U.S. Agency for International Development. Eventually, we established about 110 nutrition "self-help" education centers around the country. The aim of these efforts in the Philippines was simple: make sure that children were getting as much protein as possible. It was widely thought that much of the childhood malnutrition in the world was caused by a lack of protein, especially from animal-based foods. Universities and governments around the world were working to alleviate a perceived "protein gap" in the developing world.

In this project, however, I uncovered a dark secret. Children who ate the highest-protein diets were the ones most likely to get liver cancer! They were the children of the wealthiest families.

I then noticed a research report from India that had some very provocative, relevant findings. Indian researchers had studied two groups of rats. In one group, they administered the cancer causing
aflatoxin, then fed a diet that was composed of 20% protein, a level near what many of us consume in the West. In the other group, they administered the same amount of aflatoxin, but then fed a diet that was only composed of 5% protein. Incredibly, every single animal that consumed the 20% protein diet had evidence of liver cancer, and every single animal that consumed a 5% protein diet avoided liver cancer. It was a 100 to 0 score, leaving no doubt that nutrition trumped chemical carcinogens, even very potent carcinogens, in controlling cancer.

This information countered everything I had been taught. It was heretical to say that protein wasn't healthy, let alone say it promoted cancer. It was a defining moment in my career. Investigating such a provocative question so early in my career was not a very wise choice. Questioning protein and animal-based foods in general ran the risk of my being labeled a heretic, even if it passed the test of "good science."

But I never was much for following directions just for the sake of following directions. When I first learned to drive a team of horses or herd cattle, to hunt animals, to fish our creek or to work in the fields, I came to accept that independent thinking was part of the deal. It had to be. Encountering problems in the field meant that I had to figure out what to do next. It was a great classroom, as any farm boy can tell you. That sense of independence has stayed with me
until today.

So, faced with a difficult decision, I decided to start an in-depth laboratory program that would investigate the role of nutrition, especially protein, in the development of cancer. My colleagues and I were cautious in framing our hypotheses, rigorous in our methodology and conservative in interpreting our findings. I chose to do this research at a very basic science level, studying the biochemical details of cancer formation. It was important to understand not only whether but also how protein might promote cancer. It was the best of all worlds. By carefully following the rules of good science, I was able to study a provocative topic without provoking knee-jerk responses that arise with radical ideas. Eventually, this research became handsomely funded for twenty-seven years by the best reviewed and most competitive funding sources [mostly the National Institutes of Health (NIH), the American Cancer Society and the American Institute for Cancer Research]. Then our results were reviewed (a second time) for publication in many of the best scientific journals.

What we found was shocking. Low-protein diets inhibited the initiation of cancer by aflatoxin, regardless of how much of this carcinogen was administered to these animals. After cancer initiation was completed, low-protein diets also dramatically blocked subsequent cancer growth. In other words, the cancer-producing effects of this highly carcinogenic chemical were rendered insignificant by a low-protein diet. In fact, dietary protein proved to be so powerful in its effect that we could turn on and turn off cancer growth simply by changing the level consumed.

Furthermore, the amounts of protein being fed were those that we humans routinely consume. We didn't use extraordinary levels, as is so often the case in carcinogen studies. But that's not all. We found that not all proteins had this effect. What protein consistently and strongly promoted cancer? Casein, which makes up 87% of cow's milk protein, promoted all stages of the cancer process. What type of protein did not promote cancer, even at high levels of intake? The safe proteins were from plants, including wheat and soy. As this picture came into view, it began to challenge and then to shatter some of my most cherished assumptions.

These experimental animal studies didn't end there. I went on to direct the most comprehensive study of diet, lifestyle and disease ever done with humans in the history of biomedical research. It was a massive undertaking jointly arranged through Cornell University, Oxford University and the Chinese Academy of Preventive Medicine. The New York Times called it the "Grand Prix of Epidemiology." This project surveyed a vast range of diseases and diet and lifestyle factors in rural China and, more recently, in Taiwan. More commonly known as the China Study, this project eventually produced more than 8,000 statistically significant associations between various dietary factors and disease!

What made this project especially remarkable is that, among the many associations that are relevant to diet and disease, so many pointed to the same finding: people who ate the most animal-based foods got the most chronic disease. Even relatively small intakes of animal-based food were associated with adverse effects. People who ate the most plant-based foods were the healthiest and tended to avoid chronic disease. These results could not be ignored. From the initial experimental animal studies on animal protein effects to this massive human study on dietary patterns, the findings proved to be consistent. The health implications of consuming either animal or plant-based nutrients were remarkably different.

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Comments (5) Read through and enter the discussion with the form at the end
Dr. Yaacov Tzror - December 23, 2005 5:27 AM

an excellent book

Mafia - December 8, 2006 8:56 AM

Sir,

I have gone through the "china Study".I agree with your judgement or studes about the report.I am a bagladeshi girl and currently doing a report on cancer.I want to know more about your researches ,I too much interested on your work.Thank you.

Wayne Green - March 3, 2008 6:06 PM

Being aparently unaware of Dr. Comby's and Dr. Day's work, Colin didn't consider that it was cooking meat that causes the trouble. How did he miss Pottenger's cats and the Eskimo all raw meat diet? And the rat research in Goldot? Tsk!

Brett Stevenson - December 29, 2009 2:53 AM

Hi Wayne,

Just referenced you blog. While I acknowledge the health promoting benefits of a raw diet, I have some problems with the examples you have quoted. The Goldot experiments contrasted a plant based diet with the SAD, thus actually supporting Dr. Campbell's work. Likewise Dr. Lorraine Day adopted a vegan diet before remission of her cancer. The information on the Eskimos is somewhat conflicting but the literature suggests that their health was definitely less than ideal.

What did NOT happen in Pottenger's experiments is the animals were NOT administered a powerful carcinogen.

T. Colin Campbell's experiments conclusively demonstrated that it is the amino acid profile in animal protein that is responsible for promoting cancer.

In the group of anumals fed a 20% protein diet, all got cancer. In the group fed 5% protein, none got cancer.
"Incomplete" plant protein did not promote cancer until Dr. Campbell suppleneted the "missing" amino acid which again promoted cancer.

The cancer promoting effect of animal protein ocurred above a threshold level of 10%.

The carcinogen was the initiator, the animal protein was the promoter.

I find your cursory dismissal of Dr. Campbells' work disturbing and can only conclude that you have not read his work in earnest. My whole life I have searched for a formal course worthy of my attention. They all failed because they focused on paliative measures which failed to address the underlying causes - till now.

I have just recently finished Dr. Campbell's course and can tell you that it is money well spent. The quality of the material is unsurpassed as well as the spirit of humility in which it is prersented.

From memory, Dr. Campbell has successfully addressed the Raw objection to hs work because he was careful to design his experiments to avoid just these type of objections.

I encourage to properly read his work with an open mind and you may juust find that you are in agreement. It would not surprise me in the least to find that Dr. Campbell was actually very familiar with the work you have quoted.

aflatoxin peanut - February 22, 2012 9:49 PM

you are trustwotthy,it is an excellent book.

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