Disease Proof

The current paradigm for antibiotic use is to prescribe relatively high doses of drugs for a few days to a few weeks (or months, in the case of tuberculosis), and patients are cautioned to stay on them until all the doses are finished. However, the new study RPM describes suggests this may be doing more harm than good, looking at what happens with Plasmodium species treated with antimalarials in a mouse model…


…This study doesn't take those into account, which is a limitation--but then again, it seems designed to be more of a paper to get fellow scientists thinking about these ideas in general, rather than an exhaustive test of every potential hypothesis stemming from them.

Either way, antibiotic resistance is certainly a huge problem, and we need to find better ways to preserve the drugs we do have. Reducing their use in this manner (lower and shorter doses) is certainly worth a second look.