Disease Proof

Weight-loss drug Meridia increases heart attack and stroke risk

Meridia (Sibutramine) is an appetite suppressant, and is prescribed by physicians to help obese individuals lose weight. Meridia works by blocking the reuptake of certain neurotransmitters in the brain related to appetite. Meridia was shown to reduce food intake and body weight compared to placebo in several trials[1]. However there is no such thing as a drug without side effects.

Concerns regarding adverse cardiovascular events led to a large clinical trial in order to assess Meridia’s safety In 2009, preliminary results from the trial prompted European health officials to withdraw the drug from the market. The final results were published in 2010 in the New England Journal of Medicine, and due to those results, the manufacturer stopped producing Meridia. [2] 

The trial evaluated cardiovascular events in subjects assigned to either Meridia or placebo over approximately three years. The trial’s 10,000 participants were overweight or obese individuals over age 55 with either cardiovascular disease, type 2 diabetes, or both. The average weight loss on Meridia was 9.5 lbs. Although the researchers found no increase in death rates among Meridia users, they did find a 28% increase in risk of heart attack, and a 36% increase in risk of stroke. [3]

Weight loss is beneficial for overall health, in part because it helps to reduce the risk of cardiovascular disease. So essentially, this drug had the exact opposite of its intended effect. Plus the weight loss in this trial was miniscule – 9.5 lbs. is inconsequential for someone who is obese. The Nutritarian diet-style has helped many people lose 50 lbs., 100 lbs., or more and keep it off. Plus healthy eating does not carry an increased risk of cardiovascular events – it only reduces risk.

The bottom line: there are no shortcuts to weight loss or to good health.



1. Tziomalos, K., G.E. Krassas, and T. Tzotzas, The use of sibutramine in the management of obesity and related disorders: an update. Vasc Health Risk Manag, 2009. 5(1): p. 441-52.
2. Heavey, S. Diet drug Meridia study renews calls for U.S. ban. 9/1/2010 9/9/2010]; Available from: http://www.msnbc.msn.com/id/38962866/ns/health-diet_and_nutrition/.
3. James, W.P., et al., Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects. N Engl J Med, 2010. 363(10): p. 905-17.


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Comments (3) Read through and enter the discussion with the form at the end
MIke Rubino - September 17, 2010 6:23 PM

Dr Mike a Upenn doctor and probably a close contemporary of Dr F there {at Upenn med] was on Fox Phili TV this week and was actually chastising folks for taking this drug, claiming that its not nice to fool mother nature. I couldnt help but think that these folks werent getting this drug on their own it was being prescribed by medical doctors for them. What in the world were these doctors doing? Its frightening to me that the average doctor is so ready to hand these poisons out to their patients. I just dont trust doctors anymore and fear getting really ill and having to put my faith in one.

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Daniel Key - February 3, 2011 11:17 AM

Is it really necessary to use images like the one above? It objectifies the people in it and really makes the website seem uncouth. We know what fat people look like! In fact, a lot of people using this website probably are fat or once were fat! It drives me crazy that a website like this that usually promotes psychological and physical health would use images that objectify people's bodies like that.

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