Alright, obesity is bad—that's common knowledge—but new research in Diabetes claims that fat people actually have “sick” fat cells that make insulin-resistant proteins. Krisha McCoy of HealthDay News reports:
The fat cells we found in our obese patients were deficient in several areas," study author Guenther Boden, the Laura H. Carnell Professor of Medicine and chief of endocrinology, said in Temple press release.
Boden said that the obese people's fat cells showed stress on the endoplasmic reticulum (ER), which helps cells synthesize proteins and monitor how they are folded. When the ER is stressed, Boden explained, it produces several proteins that ultimately lead to insulin resistance. Insulin resistance, in turn, plays a major role in the development of obesity-related conditions.
The differences in the fat cells between obese and lean people may help explain the link between obesity and a higher risk of diabetes, heart disease, and stroke, Boden theorized.
Certainly follows in line with what we already know about obesity and diabetes. As Dr. Fuhrman points out, extra body fat increases risk of type-2 diabetes, which screws up insulin and can eventually cause pancreatic poop out!