Drugs used to treat preventable diseases carry serious risks (Part 2 - ARBs)

Part 2:

Angiotensin receptor blockers - anti-hypertensive drugs – linked to lung cancer and heart-related deaths

lungs

Angiotensin-receptor blockers (ARBs) are used to to treat hypertension, heart failure, and diabetic nephropathy (kidney dysfunction). They work by blocking a hormone system that regulates vascular tone and water and salt balance to control blood pressure.

Because angiotensin can affect cell survival and angiogenesis (formation of new blood vessels), two important factors in tumor growth, angiotensin is thought to play a role in cancer progression.1 To determine whether taking ARBs affected cancer risk, scientists performed a meta-analysis of several studies to uncover any possible links between ARBs and cancers. They determined that ARBs carry a increased risk of new diagnosis of any cancer (8%), and a significantly higher risk of lung cancer (25%).2

One ARB in particular, olmesartan (Benicar), is now under scrutiny by the FDA for potential cardiovascular risks. In a clinical trial testing olmesartan’s efficacy for slowing kidney damage in diabetics, there were increased rates of sudden cardiac death and death from heart attack and stroke in the subjects taking the drug compared to those taking placebo.3

In my practice, and from results recorded from members at DrFuhrman.com, even people with dramatically high blood pressure readings and dramatically high cholesterol levels have successfully returned their levels to normal without medications. In fact, as published in the medical journal Metabolism, the nutritarian diet is the most effective method to lower high cholesterol, even more effective than drugs.4 If people were very informed of these results and the risks involved with taking medications many more would certainly embrace nutritional excellence as therapy. High cholesterol and high blood pressure are lifestyle-created conditions, and the safest and most effective treatment is a high nutrient diet and exercise.

 

 

References:

1. Li H, Qi Y, Li C, et al. Angiotensin type 2 receptor-mediated apoptosis of human prostate cancer cells.Mol Cancer Ther. 2009 Dec;8(12):3255-65.

Feng Y, Wan H, Liu J, et al. The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer. Oncol Rep. 2010 Apr;23(4):941-8.

Zhao Y, Chen X, Cai1 L, et al. Angiotensin II / Angiotensin II type I receptor (AT1R) signaling promotes MCF-7 breast cancer cells survival via PI3-kinase/Akt pathway. J Cell Physiol. 2010 May 10. [Epub ahead of print]

2. Sipahi I, Debanne SM, Rowland DY, et al. Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials. Lancet Oncol. 2010 Jun 11. [Epub ahead of print]

3. Reuters: UPDATE 2 – FDA looking into death risk from Daiichi’s Benicar. http://www.reuters.com/article/idUSN1113920620100611

4. Jenkins DJ, Kendall CW, Popovich DG, et al. Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function. Metabolism. 2001 Apr;50(4):494-503.

Dr. Fuhrman warns: DO NOT take multivitamins or prenatal vitamins that contain folic acid

Folic acid supplementation is dangerous – especially for pregnant women

In a 10-year study,1,2 scientists found that women who take multivitamins containing folic acid increase their breast cancer risk by 20-30%.

Even more alarming are the associations between supplemental folic acid during pregnancy and death from breast cancer,8 and asthma and respiratory tract infections in children.5-6

Read full article

broccoli

Folic acid is the synthetic form of folate, a B vitamin, which is abundant in green vegetables. Folate protects against birth defects known as neural tube defects (NTDs). Pregnant women could safely increase their folate status and prevent NTDs by eating green vegetables, but instead they are instructed to take folic acid supplements, putting them and their children at risk. Folic acid supplements are not a substitute for folate-containing green vegetables – there are inverse associations between maternal vegetable intake and childhood cancers.12-13

Unlike synthetic folic acid, folate obtained from food sources – especially green vegetables – protects against breast and prostate cancer.

There is inverse relationship between dietary folate intake and breast and prostate cancer.14,3 Chemical differences between folate and folic acid translate into differences in uptake and processing of these two substances by the cells in the intestinal wall – excess folic acid in the circulation can occur. Luckily, folate from food comes naturally packaged in balance with other micronutrients and the body regulates its absorption.9

Rich sources of food folate

As a reference point, the U.S. RDA for folate is 400μg. Below is the approximate folate content for a 100-calorie serving.8

Spinach, raw

843 μg

Romaine lettuce

800 μg

Asparagus, cooked

750 μg

Mustard greens, raw

700 μg

Collards, raw

550 μg

Broccoli, cooked

300 μg

Edamame

225 μg

Chickpeas

150 μg

Papaya

90 μg

Orange

70 μg

Blackberries

55 μg

Avocado

50 μg

Sunflower seeds

40 μg

Quinoa, cooked

35 μg

Additional foods listed in full article

Clearly, we do not need synthetic folic acid supplements to meet our daily folate requirements.

Dr. Fuhrman’s Gentle Care Formula Multivitamin does not contain folic acid

Supplemental folic acid has also been linked to prostate cancer3, colorectal cancer4, and overall cancer mortality.7 Because folate is abundant in the nutritarian diet, and synthetic folic acid is so potentially dangerous, folic acid is not included in Dr. Fuhrman’s Gentle Care multivitamin.

Dr. Fuhrman does not recommend prenatal vitamins because of the potentially harmful ingredients, such as folic acid.

Dr. Fuhrman’s special recommendations for pregnant women:

(See full article for references)

 

Great Diet Halted Progression of Non-Hodgkins Lymphoma

Recovering your health comes in many forms. Some people, drop astonishing amounts of weight and others, like Jodi, overcome chronic skin rashes. Now take Irene, she changed her life and reversed the progression of stage-4 non-Hodgkin’s lymphoma:

When first I tasted a “blended salad” I lost my interest in eating altogether. But, now I actually look forward to my high-nutrition meals. In addition to prescribing this new way of eating, Dr. Fuhrman also recommended certain supplements that would best complement my eating regimen, such as Osteo-Sun, and Gentle-Care multi-vitamins.

I lost about 35 to 40 pounds in the first three months of eating for life. My cholesterol level dropped from 238 to 164! My other blood readings as well were excellent and have remained so, although I gained about 12 of those pounds back, where my weight has stabilized. And, in visit after visit to the oncologist, it did not seem that my disease was advancing beyond the original tumor that was located in my groin.

After 2-1/2 years of talking about the possibility of undergoing systemic chemotherapy, the doctor decided to use local radiation on that tumor as the preferred treatment of my disease, even though original tests had proved that I was a stage 4 case. The tumor melted away, and has not returned. In fact, no signs of the disease have been detected since…continue reading.

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More Problems with Multivitamins

A new report by ConsumerLab.com discovered many multivitamins either contain significantly more or less of an ingredient than they claim and some are even contaminated with lead. Scientists tested several products, including three for children, and found many exceeded tolerable limits of certain vitamins, such as vitamin A, folic acid, niacin and zinc, which can cause health risks like liver damage and bone-weakening. And a vitamin water examined had 15 times the amount folic acid stated; Reuters reports.

Our society loves magic pills and we forget foods like fruits and veggies are loaded with healthful nutrients. For example, broccoli is packed with vitamin K, which fights prostate cancer. Eating seeds and nuts helps prevent type-2 diabetes. And greens like Bok Choy contain compounds that neutralize harmful free radicals and protect against cancer.

In related news, a recent study showed high-dose beta-carotene may raise lung cancer risk. That’s why Dr. Fuhrman’s multi does not contain things like isolated beta-carotene, vitamin A and copper, which have be linked to cancer, birth defects and liver problems.

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Too Much Meat and Dairy Harm Sperm

No, no! Don’t mess with my sperm. A new study in the journal Fertility and Sterility reveals diets low in antioxidant-rich fruits and vegetables and high processed meats and full-fat dairy heighten risk of low-quality sperm. The study involved 61 men visiting a fertility clinic. Of the participants, half had poor sperm quality. Those men also had a higher intake of meat and dairy, but the other half of men had normal sperm counts and tended to eat more fruits and vegetables. Experts cite increased levels of antioxidants, like vitamin C and lycopene, for better sperm; Reuters investigates.

Antioxidants are like Superman and Batman rolled up in one. Take blueberries, they’re packed with healthful nutrients, like flavonoids, which are associated with cancer prevention and plants like broccoli protect against things such as respiratory inflammation and stroke, while antioxidant-devoid foods like hotdogs and bacon may lead to leukemia and raise lung cancer risk.

The bad news for meat keeps piling up. Just last month, a study linked processed meat to increased death risk, as high as 50% and recently red meat was pinned to blindness. Eek!

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Health-Points: Friday 3.13.09

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People Getting Hip to Antioxidants

Good news! The word “antioxidant” seems to resonate with consumers. New research in the journal Food Quality and Preference shows people associate words such as “fiber” and “antioxidants” with healthiness and willingness to try a product. Women and old people reacted the most positively to antioxidant-rich foods and both young and older people were interested in a products disease-preventing claims, especially in the short-term; NutraIngredients reports.

Fruits and vegetables are prime sources of antioxidants. Just last month, nutrients in blueberries were found to shrink cancer tumors in lab rats and Dr. Fuhrman links plant nutrients with reduced risk of cardiovascular disease and stroke.

In related news, taking concentrated beta carotene, found in most multivitamins, may increase your risk of lung cancer. High-dose beta carotene supplements interfere with the absorption of cancer-fighting antioxidants. Eek!

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Beta Carotene Supplements May Increase Lung Cancer Risk

Published in the American Journal of Epidemiology, a new 10-year analysis of more than 77,000 adults, men and women ages 50 to 76, revealed long term use of high-dose beta carotene supplements may heighten the risk of lung cancer, especially in smokers. Scientists used questionnaires to assess participants’ intake of dietary supplements and then tracked them for the next four years. These findings mirror a 2007 study showing vitamin C and E and folate supplements do not decrease the risk of lung cancer; ScienceDaily explains.

According to Dr. Fuhrman high-dose beta carotene supplements interfere with the absorption of antioxidants, like carotenoids and other antioxidants found in fruits and vegetables. This can increase cancer-risk. That’s why Dr. Fuhrman’s formulates his vitamins without beta carotene.

But getting beta carotene from veggies is just fine! Foods like carrots, mangos and oranges, as well as leafy greens like cabbage, Bok Choy and broccoli are loaded with beta carotene and other health-protecting antioxidants and phytochemicals.

Vitamins aren’t magic pills! Previous reports show vitamins alone can’t prevent heart disease or prostate cancer, i.e. a bacon cheese burger with a side of Centrum Silver isn’t healthy.

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Green Veggies Fight Pancreatic Cancer

Pancreatic cancer is a killer. But veggies kill back! New findings in the Journal of the National Cancer Institute shows glucosinolates, a phytochemical found in broccoli, cabbage, Brussels sprouts and other green vegetables, help fight pancreatic cancer. Our bodies metabolize glucosinolates into isothiocyanates. And exposing cancer cells to benzyl isothiocyanate kills them by reducing STAT-3 protein, which promotes the survival and rapid reproduction of cancer cells; Nutraingredients explains.

Green vegetables are prime cancer-fighters. The phytochemicals in foods like kale, bok choy, collard greens, arugala, and watercress halt the growth of breast cancer, inhibit the progression of lung cancer, cut the risk of colon cancer and phytonutrients also prevent toxins from damaging our DNA.

And in July, a report came out showing isothiocyanates help protect against prostate cancer too.

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Processed Meats, Cheese Linked to Lung Cancer

A new study in the American Journal of Respiratory and Critical Care Medicine claims phosphates, a common food additive, may help speed the growth of lung cancer tumors. Testing in mice determined phosphates, often found in soda and processed cheese and meat may also cause tumors. Researchers say phosphates are critical to human nutrition, but eating too much can be dangerous. In the 1990s adults consumed about 470 mg of phosphorous per day, but now they can reach 1,000 mg a day; Reuters investigates.

Another reason to avoid processed foods is they often contain harmful trans fat and cancer-causing compounds called acrylamides. Eek!