Disease Proof

Anti-Cancer: Broccoli and Soy

The Cancer Blog passes on a report exploring the anti-cancer effects of broccoli and soy. Check it out:
The researchers are convinced that there is a biological mechanism behind the protective effect. It is explained in the article that a compound resulting from the digestion of cruciferous vegetables, and genistein, an isofavone in soy, reduce the two proteins needed for breast and ovarian cancer to spread…

… The study found that when cancer cells were treated with high levels of compounds found in broccoli and soy, the drawing mechanism to the organs was reduced by 80 percent compared to untreated cells.
Dr. Fuhrman has been talking about the anti-cancer properties of cruciferous vegetables for a long time. Here’s a post about it. From "A Symphony of Phytonutrients" from Cruciferous Vegetables:
Important recent studies have shown that cruciferous vegetables and the compounds they contain can do the following:
  • Halt the growth of breast cancer cells1
  • Dramatically reduce the risk of colon cancer2
  • Prevent the replication of prostate cancer cells and induce death of cancerous cells3
  • Inhibit the progression of lung cancer4
What makes these studies even more fascinating is the discovery of the gene/diet interaction, which has shown that high intake of greens and cruciferous vegetables provides the food factors necessary to interact with--and prevent--genetic defects from creating disease. This gene/diet interaction activates a battery of many genes, initiating DNA repair and other protection mechanisms.
Makes me feel good about my baby spinach addiction.
1. Johnston N. Sulforaphane halts breast cancer cell growth. Drug Discov Today 2004;9(21): 908. Rose P, Huang Q, Ong CN, Whiteman M. Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells. Toxicol Appl Pharmacol 2005;S0041-008X.

2. Seow A, Yuan JM, Sun CL, et al. Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study. Carcinogenesis 2002;23(12): 2055-261.

3. Wu HT, Lin SH, Chen YH. Inhibition of cell proliferation and in vitro markers of angiogenesis by indole-3-carbinol, a major indole metabolite present in cruciferous vegetables. J Agric Food Chem SK, Choi S, et al. Sulphoraphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species. J Biol Chem 2005; 280(20):19911-19924. Xiao D, Srivastava SK, Lew KL, et al. Allyl isothiocyanate a constituent of cruciferous vegetables inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis. Carcinogenesis 2003;24(5):891-897.

4. Conaway CC, Wang CX, Pittman B, et al. Phenethyl isothiocyanate and sulforaphane and their n-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. Cancer Res 2005 65(18): 8548-8557.
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