Childhood diet linked to asthma prevalence, adult diet linked to asthma severity

Asthma has skyrocketed in the U.S. – the prevalence of asthma doubled between 1986 and 2005. Obesity is known to mechanically compromise proper function of the lungs and airways and is associated with asthma-related inflammation. Increased prevalence of asthma in obese individuals has been demonstrated in several studies, and there exists a dose-response relationship such that as BMI increases, asthma risk increases. Obesity is thus an independent risk factor for asthma. It is now widely believed that the rise in childhood obesity is a causative factor for the recent rise in asthma. [1, 2]

Inhaler. Photo credit: net_efekt (Flickr)

In addition to obesity, metabolic abnormalities in children and teens, such as high cholesterol, high triglycerides, and hyperinsulinemia, regardless of body weight have now been associated with asthma. This means that even if a child is of normal BMI, the standard American diet is likely taking its toll on lung function, producing early metabolic abnormalities that may set the stage for asthma, obesity, diabetes, and other chronic disease. [3]

In adults who already have asthma, previous data has been inconclusive when trying to determine whether obesity affects asthma severity. However, there is a strong connection between poor nutrition and asthma, including evidence that a single high-calorie, low-nutrient meal can spark airway inflammation, which can exacerbate asthma symptoms. Asthmatic adults consuming a single high-calorie, low nutrient meal, high in animal protein and added fat (1,000 calories worth of fast food hamburgers and hash browns) showed increased airway inflammation four hours later. Researchers compared this to a 200 calorie meal, which did not increase inflammation. [4]

Obesity, resulting from the cumulative effects of years of overeating low-nutrient, high-calorie food is a risk factor for asthma. However, deleterious effects of a low-nutrient diet on lung function occur even in the short term, and can begin early in life. Collectively, these studies tell us that asthma is another disease whose major causes include poor nutrition and a sedentary lifestyle.

Since asthma is both a lifestyle- and inflammation-related disease, dietary changes and weight loss are effective at improving asthma symptoms. A high-nutrient diet floods the body with protective micronutrients, reduces inflammation, and promotes weight loss – allowing the body to resolve the risk factors for asthma mentioned above (obesity, high cholesterol, etc.). Dr. Fuhrman has had much success using a high-nutrient diet to treat patients with asthma – many recover completely and no longer need asthma medication. He recently conducted a survey of hundreds of nutritarians, in which 82% of respondents with asthma reported a significant improvement in their symptoms after switching to a high-nutrient diet. Here is just one example:

“Dr. Fuhrman has truly been a blessing to me and my family. My husband has lost weight as so has my 11-year-old son. My son had put on a lot of weight and has asthma, making it almost impossible to complete the running portion of a physical challenge in gym class. But a couple of weeks ago, I had tears in my eyes as he crossed the finish line without wheezing!

I have more energy and have never felt this good. I tell everyone I know about Eat To Live and Eat For Health and will continue to sing Dr. Fuhrman’s praises.

-Jean”

 

References:

 

1. Sutherland, E.R., Obesity and asthma. Immunol Allergy Clin North Am, 2008. 28(3): p. 589-602, ix.
2. Canoz, M., et al., The relationship of inflammatory cytokines with asthma and obesity. Clin Invest Med, 2008. 31(6): p. E373-9.
3. Cottrell, L., et al., Metabolic Abnormalities in Children with Asthma. Am J Respir Crit Care Med, 2010.
4. High-fat meals a no-no for asthma patients, researchers find. ScienceDaily. , in American Thoracic Society 2010 International Conference. 2010: New Orleans, LA.

 

Weight-loss drug Meridia increases heart attack and stroke risk

Meridia (Sibutramine) is an appetite suppressant, and is prescribed by physicians to help obese individuals lose weight. Meridia works by blocking the reuptake of certain neurotransmitters in the brain related to appetite. Meridia was shown to reduce food intake and body weight compared to placebo in several trials[1]. However there is no such thing as a drug without side effects.

Obese couple

Concerns regarding adverse cardiovascular events led to a large clinical trial in order to assess Meridia’s safety. On September 15, an FDA advisory committee is scheduled to decide whether to keep Meridia on the market, based on the final results from the trial, which were published last week in the New England Journal of Medicine. In 2009, preliminary results from the trial prompted European health officials to withdraw the drug from the market. Meridia may soon be withdrawn in the U.S. as well [2].

The trial evaluated cardiovascular events in subjects assigned to either Meridia or placebo over approximately three years. The trial’s 10,000 participants were overweight or obese individuals over age 55 with either cardiovascular disease, type 2 diabetes, or both. The average weight loss on Meridia was 9.5 lbs. Although the researchers found no increase in death rates among Meridia users, they did find a 28% increase in risk of heart attack, and a 36% increase in risk of stroke. [3]

Weight loss is beneficial for overall health, in part because it helps to reduce the risk of cardiovascular disease. So essentially, this drug is having the exact opposite of its intended effect. Plus the weight loss in this trial was miniscule – 9.5 lbs. is inconsequential for someone who is obese. Dr. Fuhrman’s nutritarian diet-style has been shown to result in an average weight loss of 53 lbs. after two years[4], and healthy eating does not carry an increased risk of cardiovascular events – it only reduces risk.

The bottom line: there are no shortcuts to weight loss or to good health.

 

References:

1. Tziomalos, K., G.E. Krassas, and T. Tzotzas, The use of sibutramine in the management of obesity and related disorders: an update. Vasc Health Risk Manag, 2009. 5(1): p. 441-52.
2. Heavey, S. Diet drug Meridia study renews calls for U.S. ban. 9/1/2010 9/9/2010]; Available from: http://www.msnbc.msn.com/id/38962866/ns/health-diet_and_nutrition/.
3. James, W.P., et al., Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects. N Engl J Med, 2010. 363(10): p. 905-17.
4. Sarter, B., T.C. Campbell, and J. Fuhrman, Effect of a high nutrient density diet on long-term weight loss: a retrospective chart review. Altern Ther Health Med, 2008. 14(3): p. 48-53.