"A Symphony of Phytonutrients" from Cruciferous Vegetables

While fruits and vegetables are excellent sources of nutrients, the consumption of vegetables is more helpful in reducing cancer because they contain much higher amounts of cancer-protective compounds--especially green vegetables. Among these green vegetables, the cruciferous family has demonstrated the most dramatic protection against cancer. Cruciferous vegetables (broccoli, brussels sprouts, cauliflower, kale, bok choy, collards, arugala, watercress, and cabbage) contain a symphony of phytonutrients with potent anti-cancer effects.

Isothiocyanates (ITCs), which are perhaps the best studied, have been shown to provide protection against environmental carcinogen exposure by inducing detoxification pathways, thereby neutralizing potential carcinogens. These vegetables also contain indole-3-carbinol (I3C). Indole-3-carbinol has been shown to reduce the risk of breast cancer by decreasing estrogen activity.

Important recent studies have shown that cruciferous vegetables
and the compounds they contain can do the following:

* halt the growth of breast cancer cells1
* dramatically reduce the risk of colon cancer2
* prevent the replication of prostate cancer cells and induce death of cancerous cells3
* inhibit the progression of lung cancer4

What makes these studies even more fascinating is the discovery of the gene/diet interaction, which has shown that high intake of greens and cruciferous vegetables provides the food factors necessary to interact with--and prevent--genetic defects from creating disease. This gene/diet interaction activates a battery of many genes, initiating DNA repair and other protection mechanisms.

These cellular repair and detoxification mechanisms are most powerfully induced by eating a mixture of both raw and cooked cruciferous plant foods. Some of the compounds are water soluble and heat stable, and absorption is increased when cooked, for example, in a soup. Other critical ITCs are heat sensitive and are better transmitted in the raw form.

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Fishing for the Truth

Michael Hawthorne and Sam Roe of the Chicago Tribune report that the United States safety net for safeguarding consumers against the increased mercury levels in fish is in tatters. In the article the reporters detail the fate of one particular piece of fish:

Shipped from Singapore, the swordfish entered the U.S. this year without being tested for the toxic metal mercury.

When a fillet from that fish reached a display case at a supermarket in suburban Des Plaines, it carried no government warning labels, even though federal officials know swordfish often is so contaminated that young children and pregnant women should never eat it.

The Chicago Tribune actually bought and tested a portion of this fish, which produced alarming results:

When the Tribune bought and tested this particular piece of fish, the results showed not just high amounts of mercury, but levels three times the legal limit.

Hawthorne and Roe point out the dangers lurking in the fish and in the actions of U.S. health officials:

Even though mercury can cause learning disabilities in children and neurological problems in adults, regulators do not even bother to routinely check fish for metal. This leaves consumers with little idea about which fish are most hazardous.

In some cases, regulators have ignored the advice of their own scientists who concluded that mercury was far more dangerous than what consumers were being told.

In other instances, regulators have made decisions that benefited the fishing industry at the expense of public health.

In his book Eat to Live Dr. Fuhrman explains that consumption of fish creates a parodox:

Fish contains omega-3 fatty acids (EPA and DHA) that interfere with blood clotting much the same way aspirin does. Once you have significant atherosclerosis, it is helpful to take such anti-clotting agents, especially if you continue a dangerous diet. These fish derived-fats also have some effect on protecting the arterial walls from damage from other fats.

However, the best way to prevent a heart attack or stroke is to follow a high-nutrient diet with little or no animal products, thereby ensuring that such blockages don't develop in the first place. Then eating fish won't matter. In fact, the reason fish-derived fats, EPA and DHA, are not considered essential fats is that almost all people have enzymes to convert the plant-derived omega-3 fat rapidly into EPA and DHA.1

Fish is a double-edged sword, especially because fish has been shown to increase heart attack risk if polluted with mercury.2 It seems that the cardioprotective effects of eating a little fish is lost when you eat lots of fish, most likely because lots of fish exposes you to high mercury levels, which can promote lipid peroxidation.3 Lipid peroxidation plays a major role in the development of diseases such as heart disease, diabetes, and arthritis.

Dr. Fuhrman provides important information to consider when deciding whether or not to consume fish:

Higher levels of mercury found in mothers who eat more fish have been associated with birth defects, seizures, mental retardation, developmental disabilities, and cerebral palsy.4 This is mostly the result of women having eaten fish when they were pregnant. Scientists believe that fetuses are much more sensitive to mercury exposure than adults, although adults do suffer from varying degrees of brain damage from fish consumption.5 Even the FDA, which normally ignores reports on the dangers of our dangerous food practices, acknowledges that large fish such as shark, swordfish, and yellowfin and bluefin tuna, are potentially dangerous. Researchers are also concerned about other toxins concentrated in fish that can cause brain damage way before the cancers caused by chemical-carrying fish appear.

Fish with Highest and Lowest Mercury Levels

Highest
  • tilefish
  • swordfish
  • mackerel
  • shark
  • white snapper
  • tuna

Lowest
  • salmon
  • flounder
  • sole
  • tilapia
  • trout

Source: Mercury levels in seafood species. U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition. Office of Seafood, May 2001.

The bottom line: Choose fish over other animal products, but be aware that the place where it was caught, and the type of fish, matters. Don't accept recreational fish from questionable waters. Farmed fish is safer. Never eat high-mercury-content fish. Don't eat fish more than twice a week, and if you have a family history of hemorrhagic stroke, limit it further to only once a month.

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The Plastic Predator: BPA

In work published in Endocrinology University of Cincinnati researchers have found that a chemical widely used in food cans, milk container linings, water pipes, and even dental sealants could disrupt important effects of estrogen in the developing brain.

In a press release, researcher Scott Belcher, PhD, says Bisphenol A (BPA) interferes with the vital role of estrogen in female and male brain development even at low doses.

"We have now shown that environmental estrogens like BPA appear to alter, in a very complicated fashion, the normal way estrogen communicates with immature nerve cells," Dr. Belcher explained. "The developmental effects that we studied are known to be important for brain development and also for normal function of the adult brain," he said...

In the face of more than 100 studies published in peer-reviewed journals showing the detrimental effects of BPA, Dr. Belcher said, the chemical industry and federal regulatory agencies have resisted banning BPA from plastics used as food and beverage containers, despite the fact that plastics free of BPA and other toxic chemicals are available.


In the discussion forum of his member center, Dr. Fuhrman discussed plastics with members in 2004. One presented research that #2 HDPE (high density polyethylene), used for "cloudy" milk and water jugs and opaque food bottles, may be one of the safer ones. Dr. Fuhrman responded that he wasn't convinced, based on two primary factors. First of all, he wrote, water from those jugs "tastes like plastic, so it can't be good." Dr. Fuhrman also cited this study as a sample of research showing leeching from plastic into food.

The blog Mindfully has examined plastic and food extensively. I was hoping to find some handy advice to pass along about how to recognize safer kinds of plastics, but instead found only that they conclude plastic should never touch food. I can't vouch for their conclusions, but it's something to consider.

Any plastic experts out there who can shed some more light on this for us? I bet a lot of us would like to know some steps we can take to try to reduce our exposure to these kinds of toxins. Please comment away.

(Thanks to Medical Informatics for the heads up on this story.)

Is Organic Food Safer?

From Dr. Fuhrman's book Disease-Proof Your Child.

Acute lymphoblastic leukemia is up 10.7 percent over the last twenty years. Brain cancer is up 30 percent; osteogenic sarcoma, a type of bone cancer, is up 50 percent; and testicular cancer is up 60 percent in men under thirty. No one can tell us why. Scientific studies provide clues that are difficult to ignore:

  • Children whose parents work with pesticides are more likely to suffer leukemia, brain cancer, and other afflictions.
  • Studies show that childhood leukemia is related to increased pesticide use around the house.
  • Nine studies reviewed by the National Cancer Institute showed a correlation between pesticide exposure and brain cancer.
  • Exposure to weed killers in childhood increases asthma risk by more than fourfold.
All the dangers stated above are not the result of eating pesticide-treated produce. This clear link between pesticides and cancer is a result of chemical use around the home and farm.1 Clearly, it is not logical to eat organic food to avoid pesticide residue and then spray our homes with carcinogenic insecticides and weed killers used liberally in and around homes, interior plants, lawns, gardens, and even schools.

Because young children are the ones most susceptible to toxic exposures, the National Academy of Science has issued warnings and position papers stating that exposure to pesticides in early life can increase cancer rates down the road as well as increasing the occurrence of mental and immune system disorders.2

We must be careful not to expose our children to chemical cleaners, insecticides, and weed killers on our lawns. Chemicals used in pressure-treated wood used to build lawn furniture, decks, fences, and swings sets have been shown to place children at risk. When children are around, we must be vigilant to maintain a chemical-free environment.

The Environmental Protection Agency reports that the majority of pesticides now in use are probable or possible cancer causers. Studies of farm workers who work with pesticides suggest a link between pesticide use and brain cancer, Parkinson's disease, multiple myloma, leukemia, lymphoma, and cancers of the stomach, prostate, and testes.3 But the question remains, does the low level of pesticides remaining on our food present much of a danger?

Some scientists argue that the extremely low level of pesticide residue remaining on produce is insignificant and that there are naturally occurring toxins in all natural foods that are more significant. The large amount of studies performed on the typical pesticide-treated produce have demonstrated that consumption of produce, whether organic or not, is related to lower rates of cancer and disease protection, not higher rates. Certainly, it is better to eat fruits and vegetables grown and harvested using pesticides than not eating them at all. The health benefits of eating phytochemical-rich produce greatly outweigh any risk pesticide residues might pose.

It has been shown that women with higher levels of pesticides in their bloodstream have a higher risk of breast cancer.4 However, the pesticide shown in these studies to be connected to cancer was DDT, which is no longer used in food production and was banned by the U.S. government in 1972. The problem is that DDT is still in the environment and finds its way back into our food supply, predominately via shellfish and fish consumption. So purchasing organic fruit and vegetables will not lower our exposure to DDT if we are eating fish and shellfish regularly.

Keep in mind, there is a significantly larger exposure to toxic chemicals in animal products compared to plant food. By eating lower on the food chain and reducing our intake of animal products, one automatically reduces exposure to toxic chemicals. Plants have the least fat-soluble pollutants, animals that eat plants have more, and animals that eat animals have the highest levels of these toxic compounds. Fish that eat smaller fish will store the toxic compounds from every fish it ever ate, including all the fish eaten by the fish it just made a meal of. It is important to avoid lobster, shellfish, catfish, and predator fish such as tuna, bluefish, striped bass, shark, and swordfish, where toxins such as PCB, DDT, dioxin, and mercury are likely to build up due to the compounding effects of eating lots of smaller fish. One gets larger doses of more toxic compounds from these contaminated animal products than would be possible to take in from produce.

Organic food is certainly your best bet, to further limit exposure to toxic chemicals. No one knows for sure how much risk exists from pesticide residue on produce, but here's what we do know: the younger you are, the more your cells are susceptible to damage from toxins. It seems wise to feed our young children organic food whenever possible.

Of course, wash your vegetables and fruit with water and when possible, use a drop of dishwashing detergent and then rinse well to remove all detergent residues for a little more efficient cleaning. Specialty pesticide removal products have not clearly demonstrated any more effectiveness than mild soap and water.

Besides the heightened exposure to chemicals and pesticides from animal products, the most hazardous pesticides are used on some plant foods responsible for the majority of the plant-food-related dietary risk. These foods with the most pesticide residue are: strawberries, peaches, raspberries, blackberries, grapes, cherries, apples, and celery. Imported produce is also more likely to contain higher levels of pesticides.5

There is another reason to feed our children organic food when possible. Organic food usually has more nutrients than conventional.6 One study performed at the University of California at Davis found that foods grown organically had higher amounts of flavonoids, which have protective effects against both heart disease and cancer. The researchers found flavonoids were more than 50 percent higher in organic corn and strawberries. They theorized that when plants are forced to deal with the stress of insects, they produce more of these compounds, which are beneficial to humans.7 Overall, organic foods taste better, and organic agriculture protects farmers and our environment.

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